Fragment-based lead discovery (FBLD) is a powerful approach to drug discovery that involves the identification of small, low-molecular-weight compounds that bind to a target protein or enzyme. Unlike traditional high-throughput screening methods, FBLD relies on the use of small fragments of molecules that are more likely to bind to a target site with high affinity and specificity. These fragments can then be optimized and linked together to create larger, more potent compounds. FBLD has become an increasingly popular method in recent years due to its ability to identify novel chemical scaffolds and its potential for generating drugs with improved pharmacokinetic properties. By focusing on small fragments rather than large, complex molecules, FBLD offers a more efficient and cost-effective way of discovering new drugs.