Structure-Activity Relationship Expansion
Course Overview
Structure-activity relationship (SAR) studies are a critical part of medicinal chemistry and drug discovery, focusing on understanding how the chemical structure of a molecule correlates with its biological activity. SAR expansion involves systematically modifying the chemical structure of lead compounds to improve potency, selectivity, pharmacokinetics, and safety. Below are key topics and concepts within SAR expansion:
- Chemical Substitutions and Functional Group Modification
- Scaffold Hopping
- Stereochemistry and Chirality
- Ring System Modifications
- Topological and Spatial Considerations
- Hydrophobic vs. Hydrophilic Balance
- Prodrug Design
- Fragment-Based SAR
- Quantitative SAR (QSAR)
- Multi-Target SAR
- Lead Optimization
- Covalent vs. Non-Covalent Binding
- Targeting Allosteric Sites
By applying these principles, SAR expansion allows researchers to systematically refine lead compounds into drug candidates with optimal efficacy, safety, and pharmacological properties.
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Duration: 2 weeks.
8-10 hours to complete..
- Level: Basic introductory and Advanced applications.
- Prerequisite: Organic and Medicinal Chemistry background is required.
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Fee: 3000 EGP
Discount Policy for Group Registration!
- Program timeframe:
- Registration
- Be contacted to confirm the participation.
- Scheduling for the program sessions
- Supplied with the technical support to download the software required for the program.